The Enzyme Database

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EC 2.1.2.2     
Accepted name: phosphoribosylglycinamide formyltransferase
Reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide
For diagram of the early stages of purine biosynthesis, click here
Other name(s): 2-amino-N-ribosylacetamide 5′-phosphate transformylase; GAR formyltransferase; GAR transformylase; glycinamide ribonucleotide transformylase; GAR TFase; 5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase
Systematic name: 10-formyltetrahydrofolate:5′-phosphoribosylglycinamide N-formyltransferase
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9032-02-4
References:
1.  Hartman, S.C. and Buchanan, J.M. Biosynthesis of the purines. XXVI. The identification of the formyl donors of the transformylation reaction. J. Biol. Chem. 234 (1959) 1812–1816. [PMID: 13672969]
2.  Smith, G.K., Benkovic, P.A. and Benkovic, S.J. L(-)-10-Formyltetrahydrofolate is the cofactor for glycinamide ribonucleotide transformylase from chicken liver. Biochemistry 20 (1981) 4034–4036. [PMID: 7284307]
3.  Warren, L. and Buchanan, J.M. Biosynthesis of the purines. XIX. 2-Amino-N-ribosylacetamide 5′-phosphate (glycinamide ribotide) transformylase. J. Biol. Chem. 229 (1957) 613–626. [PMID: 13502326]
[EC 2.1.2.2 created 1961, modified 2000]
 
 


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