The Enzyme Database

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EC 6.3.3.1     
Accepted name: phosphoribosylformylglycinamidine cyclo-ligase
Reaction: ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole
For diagram of the early stages of purine biosynthesis, click here
Other name(s): phosphoribosylaminoimidazole synthetase; AIR synthetase; 5′-aminoimidazole ribonucleotide synthetase; 2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)
Systematic name: 2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9023-53-4
References:
1.  Levenberg, B. and Buchanan, J.M. Properties of the purines. XII. Structure, enzymatic synthesis, and metabolism of 5-aminoimidazole ribotide. J. Biol. Chem. 224 (1957) 1005–1018. [PMID: 13405929]
2.  Levenberg, B. and Buchanan, J.M. Biosynthesis of the purines. XIII. Structure, enzymatic synthesis, and metabolism of (α-N-formyl)-glycinamidine ribotide. J. Biol. Chem. 224 (1957) 1018–1027. [PMID: 13405930]
[EC 6.3.3.1 created 1961, modified 2000]
 
 


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