The Enzyme Database

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EC 6.3.4.13     
Accepted name: phosphoribosylamine—glycine ligase
Reaction: ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide
For diagram of purine biosynthesis (early stages), click here
Other name(s): phosphoribosylglycinamide synthetase; glycinamide ribonucleotide synthetase; phosphoribosylglycineamide synthetase; glycineamide ribonucleotide synthetase; 2-amino-N-ribosylacetamide 5′-phosphate kinosynthase; 5′-phosphoribosylglycinamide synthetase; GAR
Systematic name: 5-phospho-D-ribosylamine:glycine ligase (ADP-forming)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9032-01-3
References:
1.  Goldthwait, D.A., Peabody, R.A. and Greenberg, G.R. On the mechanism of synthesis of glycinamide ribotide and its formyl derivative. J. Biol. Chem. 221 (1956) 569–577. [PMID: 13357451]
2.  Hartman, S.C. and Buchanan, J.M. Biosynthesis of the purines. XXII. 2-Amino-N-ribosylacetamide-5′-phosphate kinosynthase. J. Biol. Chem. 233 (1958) 456–461. [PMID: 13563520]
[EC 6.3.4.13 created 1961 as EC 6.3.1.3, transferred 1972 to EC 6.3.4.13, modified 2000]
 
 


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