|
Your query returned 1 entry. Printable version
EC | 1.17.99.4 | ||||||||||
Accepted name: | uracil/thymine dehydrogenase | ||||||||||
Reaction: | (1) uracil + H2O + acceptor = barbiturate + reduced acceptor (2) thymine + H2O + acceptor = 5-methylbarbiturate + reduced acceptor |
||||||||||
For diagram of pyrimidine catabolism, click here | |||||||||||
Other name(s): | uracil oxidase; uracil-thymine oxidase; uracil dehydrogenase | ||||||||||
Systematic name: | uracil:acceptor oxidoreductase | ||||||||||
Comments: | Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 3.5.2.1 (barbiturase) and EC 3.5.1.95 (N-malonylurea hydrolase). Mammals, plants and other microorganisms utilize the reductive pathway, comprising EC 1.3.1.1 [dihydrouracil dehydrogenase (NAD+)] or EC 1.3.1.2 [dihydropyrimidine dehydrogenase (NADP+)], EC 3.5.2.2 (dihydropyrimidinase) and EC 3.5.1.6 (β-ureidopropionase), with the ultimate degradation products being an L-amino acid, NH3 and CO2 [5]. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9029-00-9 | ||||||||||
References: |
| ||||||||||