EC |
3.5.1.6 |
Accepted name: |
β-ureidopropionase |
Reaction: |
3-ureidopropanoate + H2O = β-alanine + CO2 + NH3 |
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For diagram of pyrimidine catabolism, click here |
Glossary: |
3-ureidopropanoate = N-carbamoyl-β-alanine |
Other name(s): |
N-carbamoyl-β-alanine amidohydrolase |
Systematic name: |
3-ureidopropanoate amidohydrolase |
Comments: |
The animal enzyme also acts on β-ureidoisobutyrate. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9027-27-4 |
References: |
1. |
Campbell, L.L. Reductive degradation of pyrimidines. 5. Enzymatic conversion of N-carbamyl-β-alanine to β-alanine, carbon dioxide, and ammonia. J. Biol. Chem. 235 (1960) 2375–2378. [PMID: 13849303] |
2. |
Caravaca, J. and Grisolia, S. Enzymatic decarbamylation of carbamyl β-alanine and carbamyl β-aminoisobutyric acid. J. Biol. Chem. 231 (1958) 357–365. [PMID: 13538975] |
3. |
Traut, T.W. and Loechel, S. Pyrimidine catabolism: individual characterization of the three sequential enzymes with a new assay. Biochemistry 23 (1984) 2533–2539. [PMID: 6433973] |
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[EC 3.5.1.6 created 1961] |
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