| EC |
2.7.7.48 |
| Accepted name: |
RNA-directed RNA polymerase |
| Reaction: |
nucleoside triphosphate + RNAn = diphosphate + RNAn+1 |
| Other name(s): |
RNA nucleotidyltransferase (RNA-directed); RNA nucleotidyltransferase (RNA-directed); RNA-dependent ribonucleate nucleotidyltransferase; 3D polymerase; PB1 proteins; PB2 proteins; phage f2 replicase; polymerase L; Q-β replicase; phage f2 replicase; ribonucleic acid replicase; ribonucleic acid-dependent ribonucleate nucleotidyltransferase; ribonucleic acid-dependent ribonucleic acid polymerase; ribonucleic replicase; ribonucleic synthetase; RNA replicase; RNA synthetase; RNA transcriptase; RNA-dependent ribonucleate nucleotidyltransferase; RDRP; RNA-dependent RNA polymerase; RNA-dependent RNA replicase; transcriptase |
| Systematic name: |
nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed) |
| Comments: |
Catalyses RNA-template-directed extension of the 3′- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. See also EC 2.7.7.6 DNA-directed RNA polymerase. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9026-28-2 |
| References: |
| 1. |
August, J.T., Cooper, S., Shapiro, L. and Zinder, N.D. RNA phage induced RNA polymerase. Cold Spring Harbour Symp. Quant. Biol. 28 (1963) 95–97. |
| 2. |
Haruna, J., Nozu, K., Ohtaka, Y. and Spiegelman, S. An RNA "Replicase" induced by and selective for a viral RNA: isolation and properties. Proc. Natl. Acad. Sci. USA 50 (1963) 905–911. [PMID: 14082356] |
| 3. |
Weismann, C., Simon, L. and Ochoa, S. Induction by an RNA phage of an enzyme catalyzing incorporation of ribonucleotides into ribonucleic acid. Proc. Natl. Acad. Sci. USA 49 (1963) 407–414. [PMID: 13999778] |
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| [EC 2.7.7.48 created 1981, modified 1982] |
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