ExplorEnz: EC 2.7.7.48

2.7.7.48

Accepted name:

RNA-directed RNA polymerase

Reaction:

nucleoside triphosphate + RNA_n = diphosphate + RNA_n+1

Other name(s):

RNA nucleotidyltransferase (RNA-directed); RNA nucleotidyltransferase (RNA-directed); RNA-dependent ribonucleate nucleotidyltransferase; 3D polymerase; PB1 proteins; PB2 proteins; phage f2 replicase; polymerase L; Q-β replicase; phage f2 replicase; ribonucleic acid replicase; ribonucleic acid-dependent ribonucleate nucleotidyltransferase; ribonucleic acid-dependent ribonucleic acid polymerase; ribonucleic replicase; ribonucleic synthetase; RNA replicase; RNA synthetase; RNA transcriptase; RNA-dependent ribonucleate nucleotidyltransferase; RDRP; RNA-dependent RNA polymerase; RNA-dependent RNA replicase; transcriptase

Systematic name:

nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)

Comments:

Catalyses RNA-template-directed extension of the 3′- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. See also EC 2.7.7.6 DNA-directed RNA polymerase.

References:

1.	August, J.T., Cooper, S., Shapiro, L. and Zinder, N.D. RNA phage induced RNA polymerase. Cold Spring Harbour Symp. Quant. Biol. 28 (1963) 95–97.
2.	Haruna, J., Nozu, K., Ohtaka, Y. and Spiegelman, S. An RNA "Replicase" induced by and selective for a viral RNA: isolation and properties. Proc. Natl. Acad. Sci. USA 50 (1963) 905–911. [PMID: 14082356]
3.	Weismann, C., Simon, L. and Ochoa, S. Induction by an RNA phage of an enzyme catalyzing incorporation of ribonucleotides into ribonucleic acid. Proc. Natl. Acad. Sci. USA 49 (1963) 407–414. [PMID: 13999778]

[EC 2.7.7.48 created 1981, modified 1982]