The Enzyme Database

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Accepted name: DNA-directed RNA polymerase
Reaction: nucleoside triphosphate + RNAn = diphosphate + RNAn+1
Other name(s): RNA polymerase; RNA nucleotidyltransferase (DNA-directed); RNA polymerase I; RNA polymerase II; RNA polymerase III; C RNA formation factors; deoxyribonucleic acid-dependent ribonucleic acid polymerase; DNA-dependent ribonucleate nucleotidyltransferase; DNA-dependent RNA nucleotidyltransferase; DNA-dependent RNA polymerase; ribonucleate nucleotidyltransferase; ribonucleate polymerase; C ribonucleic acid formation factors; ribonucleic acid nucleotidyltransferase; ribonucleic acid polymerase; ribonucleic acid transcriptase; ribonucleic polymerase; ribonucleic transcriptase; RNA nucleotidyltransferase; RNA transcriptase; transcriptase; RNA nucleotidyltransferase I
Systematic name: nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
Comments: Catalyses DNA-template-directed extension of the 3′- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to α-amanitin, and the type of RNA synthesized. See also EC (polynucleotide adenylyltransferase) and EC (RNA-directed RNA polymerase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9014-24-8
1.  Krakow, J.S. and Ochoa, S. RNA polymerase from Azotobacter vinelandii. Methods Enzymol. 6 (1963) 11–17.
2.  Mans, R.J. and Walter, T.J. Transfer RNA-primed oligoadenylate synthesis in maize seedlings. II. Primer, substrate and metal specificities and size of product. Biochim. Biophys. Acta 247 (1971) 113–121. [DOI] [PMID: 4946277]
3.  Roeder, R.G. In: Losick, R. and Chamberlin, M. (Ed.), RNA Polymerase, Cold Spring Harbor Laboratory, 1976, p. 285.
4.  Sheldon, R., Jurale, C. and Kates, J. Detection of polyadenylic acid sequences in viral and eukaryotic RNA(poly(U)-cellulose columns-poly(U) filters-fiberglass-HeLa cells-bacteriophage T4). Proc. Natl. Acad. Sci. USA 69 (1972) 417–421. [DOI] [PMID: 4501121]
5.  Weaver, R.F., Blatti, S.P. and Rutter, W.J. Molecular structures of DNA-dependent RNA polymerases (II) from calf thymus and rat liver. Proc. Natl. Acad. Sci. USA 68 (1971) 2994–2999. [DOI] [PMID: 5289245]
[EC created 1961, modified 1981, modified 1982, modified 1989]

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