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Your query returned 1 entry. 
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| EC | 1.14.13.178 | ||||
| Accepted name: | methylxanthine N1-demethylase | ||||
| Reaction: | (1) caffeine + O2 + NAD(P)H + H+ = theobromine + NAD(P)+ + H2O + formaldehyde (2) theophylline + O2 + NAD(P)H + H+ = 3-methylxanthine + NAD(P)+ + H2O + formaldehyde (3) paraxanthine + O2 + NAD(P)H + H+ = 7-methylxanthine + NAD(P)+ + H2O + formaldehyde |
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| Glossary: | caffeine = 1,3,7-trimethylxanthine theobromine = 3,7-dimethylxanthine theophylline = 1,3-dimethylxanthine paraxanthine = 1,7-dimethylxanthine |
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| Other name(s): | ndmA (gene name) | ||||
| Systematic name: | caffeine:oxygen oxidoreductase (N1-demethylating) | ||||
| Comments: | A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.179, methylxanthine N3-demethylase, and has a 5-fold higher activity with NADH than with NADPH [2]. Also demethylate 1-methylxantine with lower efficiency. Forms part of the degradation pathway of methylxanthines. | ||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||
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