Catalyses the first step in the degradation of chlorobenzoate in Pseudomonas. In many microorganisms, this activity comprises three separate enzymes, EC 184.108.40.206 (4-chlorobenzoate—CoA ligase), EC 220.127.116.11 (4-chlorobenzoyl-CoA dehalogenase) and EC 18.104.22.168 (4-hydroxybenzoyl-CoA thioesterase).
Müller, R., Thiele, J., Klages, U. and Lingens, F. Incorporation of [18O]water into 4-hydroxybenzoic acid in the reaction of 4-chlorobenzoate dehalogenase from Pseudomonas spec. CBS 3. Biochem. Biophys. Res. Commun.124 (1984) 178–182. [DOI] [PMID: 6497878]
Heppel, L.A. and Porterfield, V.T. Enzymatic dehalogenation of certain brominated and chlorinated compounds. J. Biol. Chem.176 (1948) 763–769. [PMID: 18889931]