The Enzyme Database

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EC 3.6.3.55     
Accepted name: tungstate-importing ATPase
Reaction: ATP + H2O + tungstate[side 1] = ADP + phosphate + tungstate[side 2]
Other name(s): tungstate transporter; WtpABC; TupABC; tungstate-specific ABC transporter
Systematic name: ATP phosphohydrolase (tungstate-importing)
Comments: An ABC-type (ATP-binding cassette-type) ATPase. The enzymes from the archaeon Pyrococcus furiosus, the Gram-positive bacterium Eubacterium acidaminophilum and the Gram-negative bacterium Campylobacter jejuni transport tungsten into the cell for incorporation into tungsten-dependent enzymes.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Makdessi, K., Andreesen, J.R. and Pich, A. Tungstate uptake by a highly specific ABC transporter in Eubacterium acidaminophilum. J. Biol. Chem. 276 (2001) 24557–24564. [PMID: 11292832]
2.  Bevers, L.E., Hagedoorn, P.L., Krijger, G.C. and Hagen, W.R. Tungsten transport protein A (WtpA) in Pyrococcus furiosus: the first member of a new class of tungstate and molybdate transporters. J. Bacteriol. 188 (2006) 6498–6505. [PMID: 16952940]
3.  Smart, J.P., Cliff, M.J. and Kelly, D.J. A role for tungsten in the biology of Campylobacter jejuni: tungstate stimulates formate dehydrogenase activity and is transported via an ultra-high affinity ABC system distinct from the molybdate transporter. Mol. Microbiol. 74 (2009) 742–757. [PMID: 19818021]
[EC 3.6.3.55 created 2013]
 
 


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