EC |
7.3.2.6 |
Accepted name: |
ABC-type tungstate transporter |
Reaction: |
ATP + H2O + tungstate-[tungstate-binding protein][side 1] = ADP + phosphate + tungstate[side 2] + [tungstate-binding protein][side 1] |
Other name(s): |
tungstate transporter; tungstate-importing ATPase; tungstate-specific ABC transporter; WtpABC; TupABC |
Systematic name: |
ATP phosphohydrolase (ABC-type, tungstate-importing) |
Comments: |
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme, characterized from the archaeon Pyrococcus furiosus, the Gram-positive bacterium Eubacterium acidaminophilum and the Gram-negative bacterium Campylobacter jejuni, interacts with an extracytoplasmic substrate binding protein and mediates the import of tungstate into the cell for incorporation into tungsten-dependent enzymes. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Makdessi, K., Andreesen, J.R. and Pich, A. Tungstate uptake by a highly specific ABC transporter in Eubacterium acidaminophilum. J. Biol. Chem. 276 (2001) 24557–24564. [DOI] [PMID: 11292832] |
2. |
Bevers, L.E., Hagedoorn, P.L., Krijger, G.C. and Hagen, W.R. Tungsten transport protein A (WtpA) in Pyrococcus furiosus: the first member of a new class of tungstate and molybdate transporters. J. Bacteriol. 188 (2006) 6498–6505. [DOI] [PMID: 16952940] |
3. |
Smart, J.P., Cliff, M.J. and Kelly, D.J. A role for tungsten in the biology of Campylobacter jejuni: tungstate stimulates formate dehydrogenase activity and is transported via an ultra-high affinity ABC system distinct from the molybdate transporter. Mol. Microbiol. 74 (2009) 742–757. [DOI] [PMID: 19818021] |
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[EC 7.3.2.6 created 2013 as EC 3.6.3.55, transferred 2018 to EC 7.3.2.6] |
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