The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 3.5.4.30     
Accepted name: dCTP deaminase (dUMP-forming)
Reaction: dCTP + 2 H2O = dUMP + diphosphate + NH3
Systematic name: dCTP aminohydrolase (dUMP-forming)
Comments: Requires Mg2+. Is highly specific for dCTP as substrate as dCMP, CTP, CDP, CMP, cytosine or deoxycytosine are not deaminated. While most bacteria require two enzymes to form dUMP from dCTP (EC 3.5.4.13, dCTP deaminase and EC 3.6.1.23, dUTP diphosphatase), the archaeon Methanocaldococcus jannaschii uses a single enzyme to carry out both functions. This enzyme can also act as a dUTP diphosphatase, but more slowly.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
References:
1.  Li, H., Xu, H., Graham, D.E. and White, R.H. The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase. J. Biol. Chem. 278 (2003) 11100–11106. [PMID: 12538648]
[EC 3.5.4.30 created 2003]
 
 


Data © 2001–2017 IUBMB
Web site © 2005–2017 Andrew McDonald