The Enzyme Database

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EC 3.2.1.45     
Accepted name: glucosylceramidase
Reaction: a D-glucosyl-N-acylsphingosine + H2O = D-glucose + a ceramide
For diagram of glycolipid biosynthesis, click here
Glossary: a ceramide = an N-acylsphingosine
Other name(s): psychosine hydrolase; glucosphingosine glucosylhydrolase; GlcCer-β-glucosidase; β-D-glucocerebrosidase; glucosylcerebrosidase; β-glucosylceramidase; ceramide glucosidase; glucocerebrosidase; glucosylsphingosine β-glucosidase; glucosylsphingosine β-D-glucosidase
Systematic name: D-glucosyl-N-acylsphingosine glucohydrolase
Comments: Also acts on glucosylsphingosine (cf. EC 3.2.1.62 glycosylceramidase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37228-64-1
References:
1.  Brady, R.O., Kanfer, J.N. and Shapiro, D. The metabolism of glucocerebrosides. I. Preparation and properties of a glucocerebroside-cleaving enzyme from spleen tissue. J. Biol. Chem. 240 (1966) 39–43. [PMID: 14253443]
2.  Vaccaro, A.M., Muscillo, M. and Suzuki, K. Characterization of human glucosylsphingosine glucosyl hydrolase and comparison with glucosylceramidase. Eur. J. Biochem. 146 (1985) 315–321. [PMID: 3967661]
[EC 3.2.1.45 created 1972]
 
 


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