Broad specificity [cf. EC 22.214.171.124 (glucosylceramidase) and EC 126.96.36.199 (galactosylceramidase)]. Also hydrolyses phlorizin to phloretin and glucose. The intestinal enzyme is a complex that also catalyses the reaction of EC 188.8.131.52 lactase.
Leese, H.J. and Semenza, G. On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase. J. Biol. Chem.248 (1973) 8170–8173. [PMID: 4752949]
Lorenz-Meyer, H., Blum, A.L., Haemmerli, H.P. and Semenza, G. A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase. Eur. J. Clin. Invest.2 (1972) 326–331. [DOI] [PMID: 5082068]
Malathi, P. and Crane, R.K. Phlorizin hydrolase: a β-glucosidase of hamster intestinal brush border membrane. Biochim. Biophys. Acta173 (1969) 245–256. [DOI] [PMID: 5774775]