Broad specificity [cf. EC 220.127.116.11 (glucosylceramidase) and EC 18.104.22.168 (galactosylceramidase)]. Also hydrolyses phlorizin to phloretin and glucose. The intestinal enzyme is a complex that also catalyses the reaction of EC 22.214.171.124 lactase.
Leese, H.J. and Semenza, G. On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase. J. Biol. Chem.248 (1973) 8170–8173. [PMID: 4752949]
Lorenz-Meyer, H., Blum, A.L., Haemmerli, H.P. and Semenza, G. A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase. Eur. J. Clin. Invest.2 (1972) 326–331. [DOI] [PMID: 5082068]
Malathi, P. and Crane, R.K. Phlorizin hydrolase: a β-glucosidase of hamster intestinal brush border membrane. Biochim. Biophys. Acta173 (1969) 245–256. [DOI] [PMID: 5774775]