The Enzyme Database

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EC 2.5.1.76     
Accepted name: cysteate synthase
Reaction: O-phospho-L-serine + sulfite = L-cysteate + phosphate
Systematic name: sulfite:O-phospho-L-serine sulfotransferase (phosphate-hydrolysing, L-cysteate-forming)
Comments: A pyridoxal-phosphate protein. It is highly specific for O-phospho-L-serine and sulfite. The reaction proceeds through a dehydroalanine (2-aminoacrylic acid) intermediate. The enzyme from Methanosarcina acetivorans is evolutionarily related to threonine synthase (EC 4.2.3.1), but the reaction is more similar to that of O-phosphoserine sulfhydrylase (EC 2.5.1.65).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Graham, D.E., Taylor, S.M., Wolf, R.Z. and Namboori, S.C. Convergent evolution of coenzyme M biosynthesis in the Methanosarcinales: cysteate synthase evolved from an ancestral threonine synthase. Biochem. J. 424 (2009) 467–478. [PMID: 19761441]
[EC 2.5.1.76 created 2009]
 
 


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