The Enzyme Database

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EC 2.4.2.44     
Accepted name: S-methyl-5′-thioinosine phosphorylase
Reaction: S-methyl-5′-thioinosine + phosphate = hypoxanthine + S-methyl-5-thio-α-D-ribose 1-phosphate
Other name(s): MTIP; MTI phosphorylase; methylthioinosine phosphorylase
Systematic name: S-methyl-5′-thioinosine:phosphate S-methyl-5-thio-α-D-ribosyl-transferase
Comments: No activity with S-methyl-5′-thioadenosine. The catabolism of of 5′-methylthioadenosine in Pseudomonas aeruginosa involves deamination to S-methyl-5′-thioinosine (EC 3.5.4.31, S-methyl-5′-thioadenosine deaminase) and phosphorolysis to hypoxanthine [1].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Guan, R., Ho, M.C., Almo, S.C. and Schramm, V.L. Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing. Biochemistry 50 (2011) 1247–1254. [PMID: 21197954]
[EC 2.4.2.44 created 2011]
 
 


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