The enzyme from Thermotoga maritima also functions as S-adenosylhomocysteine deaminase (EC 220.127.116.11) and has some activity against adenosine. Adenosine 5′-phosphate and S-adenosyl-L-methionine (SAM) are not substrates.
Hermann, J.C., Marti-Arbona, R., Fedorov, A.A., Fedorov, E., Almo, S.C., Shoichet, B.K. and Raushel, F.M. Structure-based activity prediction for an enzyme of unknown function. Nature448 (2007) 775–779. [DOI] [PMID: 17603473]