EC |
2.4.1.12 |
Accepted name: |
cellulose synthase (UDP-forming) |
Reaction: |
UDP-α-D-glucose + [(1→4)-β-D-glucosyl]n = UDP + [(1→4)-β-D-glucosyl]n+1 |
Other name(s): |
UDP-glucose—β-glucan glucosyltransferase; UDP-glucose-cellulose glucosyltransferase; GS-I; β-1,4-glucosyltransferase; uridine diphosphoglucose-1,4-β-glucan glucosyltransferase; β-1,4-glucan synthase; β-1,4-glucan synthetase; β-glucan synthase; 1,4-β-D-glucan synthase; 1,4-β-glucan synthase; glucan synthase; UDP-glucose-1,4-β-glucan glucosyltransferase; uridine diphosphoglucose-cellulose glucosyltransferase; UDP-glucose:1,4-β-D-glucan 4-β-D-glucosyltransferase; UDP-glucose:(1→4)-β-D-glucan 4-β-D-glucosyltransferase |
Systematic name: |
UDP-α-D-glucose:(1→4)-β-D-glucan 4-β-D-glucosyltransferase (configuration-inverting) |
Comments: |
Involved in the synthesis of cellulose. A similar enzyme utilizes GDP-glucose [EC 2.4.1.29 cellulose synthase (GDP-forming)]. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9027-19-4 |
References: |
1. |
Glaser, L. The synthesis of cellulose in cell-free extracts of Acetobacter xylinum. J. Biol. Chem. 232 (1958) 627–636. [PMID: 13549448] |
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[EC 2.4.1.12 created 1961] |
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EC |
2.4.1.120 |
Accepted name: |
sinapate 1-glucosyltransferase |
Reaction: |
UDP-α-D-glucose + sinapate = UDP + 1-O-sinapoyl-β-D-glucose |
Glossary: |
sinapate = (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate |
Other name(s): |
uridine diphosphoglucose-sinapate glucosyltransferase; UDP-glucose:sinapic acid glucosyltransferase; uridine 5′-diphosphoglucose-hydroxycinnamic acid acylglucosyltransferase; UDP-glucose:sinapate D-glucosyltransferase |
Systematic name: |
UDP-α-D-glucose:sinapate D-glucosyltransferase |
Comments: |
Some other hydroxycinnamates, including 4-coumarate, ferulate and caffeate, can act as acceptors, but more slowly. Only glucose esters, not glucosides, are formed (cf. EC 2.4.1.126 hydroxycinnamate 4-β-glucosyltransferase). |
Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, CAS registry number: 74082-53-4 |
References: |
1. |
Strack, D. Enzymatic synthesis of 1-sinapoylglucose from free sinapic acid and UDP-glucose by a cell free system from Raphanus sativus seedlings. Z. Naturforsch. C: Biosci. 35 (1980) 204–208. |
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[EC 2.4.1.120 created 1984] |
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EC |
2.4.1.121 |
Accepted name: |
indole-3-acetate β-glucosyltransferase |
Reaction: |
UDP-glucose + (indol-3-yl)acetate = UDP + 1-O-(indol-3-yl)acetyl-β-D-glucose |
Other name(s): |
uridine diphosphoglucose-indoleacetate glucosyltransferase; UDPG-indol-3-ylacetyl glucosyl transferase; UDP-glucose:indol-3-ylacetate glucosyltransferase; indol-3-ylacetylglucose synthase; UDP-glucose:indol-3-ylacetate glucosyl-transferase; IAGlu synthase; IAA-glucose synthase; UDP-glucose:indole-3-acetate β-D-glucosyltransferase |
Systematic name: |
UDP-glucose:(indol-3-yl)acetate β-D-glucosyltransferase |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 74082-56-7 |
References: |
1. |
Michalczuk, L. and Bandurski, R.S. Enzymic synthesis of 1-O-indol-3-ylacetyl-β-D-glucose and indol-3-ylacetyl-myo-inositol. Biochem. J. 207 (1982) 273–281. [PMID: 6218801] |
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[EC 2.4.1.121 created 1984] |
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EC |
2.4.1.122 |
Accepted name: |
N-acetylgalactosaminide β-1,3-galactosyltransferase |
Reaction: |
UDP-α-D-galactose + N-acetyl-α-D-galactosaminyl-R = UDP + β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl-R |
Other name(s): |
glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase; uridine diphosphogalactose-mucin β-(1→3)-galactosyltransferase; UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-β-D-galactosyltransferase; UDP-Gal:α-D-GalNAc-1,3-α-D-GalNAc-diphosphoundecaprenol β-1,3-galactosyltransferase; wbnJ (gene name); wbiP (gene name); C1GALT1 (gene name); UDP-α-D-galactose:glycoprotein-N-acetyl-D-galactosamine 3-β-D-galactosyltransferase |
Systematic name: |
UDP-α-D-galactose:N-acetyl-α-D-galactosaminyl-R β-1,3-galactosyltransferase (configuration-inverting) |
Comments: |
The eukaryotic enzyme can act on non-reducing O-serine-linked N-acetylgalactosamine residues in mucin glycoproteins, forming the T antigen. The bacterial enzyme, found in some pathogenic strains, is involved in biosynthesis of the O-antigen repeating unit. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 97089-61-7 |
References: |
1. |
Hesford, F.J., Berger, E.G. and van den Eijnden, D.H. Identification of the product formed by human erythrocyte galactosyltransferase. Biochim. Biophys. Acta 659 (1981) 302–311. [DOI] [PMID: 6789880] |
2. |
Mendicino, J., Sivakami, S., Davila, M. and Chandrasekaran, E.V. Purification and properties of UDP-gal:N-acetylgalactosaminide mucin:β1,3-galactosyltransferase from swine trachea mucosa. J. Biol. Chem. 257 (1982) 3987–3994. [PMID: 6801057] |
3. |
Schachter, H., Narasimhan, S., Gleeson, P. and Vella, G. Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type. Methods Enzymol. 98 (1983) 98–134. [PMID: 6366476] |
4. |
Ju, T., Brewer, K., D'Souza, A., Cummings, R.D. and Canfield, W.M. Cloning and expression of human core 1 β1,3-galactosyltransferase. J. Biol. Chem. 277 (2002) 178–186. [DOI] [PMID: 11677243] |
5. |
Yi, W., Perali, R.S., Eguchi, H., Motari, E., Woodward, R. and Wang, P.G. Characterization of a bacterial β-1,3-galactosyltransferase with application in the synthesis of tumor-associated T-antigen mimics. Biochemistry 47 (2008) 1241–1248. [DOI] [PMID: 18179256] |
6. |
Woodward, R., Yi, W., Li, L., Zhao, G., Eguchi, H., Sridhar, P.R., Guo, H., Song, J.K., Motari, E., Cai, L., Kelleher, P., Liu, X., Han, W., Zhang, W., Ding, Y., Li, M. and Wang, P.G. In vitro bacterial polysaccharide biosynthesis: defining the functions of Wzy and Wzz. Nat. Chem. Biol. 6 (2010) 418–423. [DOI] [PMID: 20418877] |
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[EC 2.4.1.122 created 1984 (EC 2.4.1.307 created 2013, incorporated 2016), modified 2016] |
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EC |
2.4.1.123 |
Accepted name: |
inositol 3-α-galactosyltransferase |
Reaction: |
UDP-α-D-galactose + myo-inositol = UDP + O-α-D-galactosyl-(1→3)-1D-myo-inositol |
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For diagram of stachyose biosynthesis, click here |
Glossary: |
O-α-D-galactosyl-(1→3)-1D-myo-inositol = galactinol |
Other name(s): |
UDP-D-galactose:inositol galactosyltransferase; UDP-galactose:myo-inositol 1-α-D-galactosyltransferase; UDPgalactose:myo-inositol 1-α-D-galactosyltransferase; galactinol synthase; inositol 1-α-galactosyltransferase; uridine diphosphogalactose-inositol galactosyltransferase; GolS; UDP-galactose:myo-inositol 3-α-D-galactosyltransferase |
Systematic name: |
UDP-α-D-galactose:myo-inositol 3-α-D-galactosyltransferase |
Comments: |
An enzyme from plants involved in the formation of raffinose and stachyose [cf. EC 2.4.1.67 (galactinol—raffinose galactosyltransferase) and EC 2.4.1.82 (galactinol—sucrose galactosyltransferase)]. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 79955-89-8 |
References: |
1. |
Pharr, D.M., Sox, H.N., Locy, R.D. and Huber, S.C. Partial characterization of the galactinol forming enzyme from leaves of Cucumis sativus L. Plant Sci. Lett. 23 (1981) 25–33. |
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[EC 2.4.1.123 created 1984, modified 2003] |
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EC
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2.4.1.124
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Transferred entry: | N-acetyllactosamine 3-α-galactosyltransferase. Now EC 2.4.1.87, N-acetyllactosaminide 3-α-galactosyltransferase
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[EC 2.4.1.124 created 1984, deleted 2002] |
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EC |
2.4.1.125 |
Accepted name: |
sucrose—1,6-α-glucan 3(6)-α-glucosyltransferase |
Reaction: |
(1) sucrose + [(1→6)-α-D-glucosyl]n = D-fructose + [(1→6)-α-D-glucosyl]n+1 (2) sucrose + [(1→6)-α-D-glucosyl]n = D-fructose + (1→3)-α-D-glucosyl-[(1→6)-α-D-glucosyl]n |
Other name(s): |
water-soluble-glucan synthase (misleading); GTF-I; GTF-S; GTF-SI; sucrose-1,6-α-glucan 3(6)-α-glucosyltransferase; sucrose:1,6-α-D-glucan 3-α- and 6-α-glucosyltransferase; sucrose:1,6-, 1,3-α-D-glucan 3-α- and 6-α-D-glucosyltransferase; sucrose:1,6-α-D-glucan 3(6)-α-D-glucosyltransferase; gtfB (gene name); gtfC (gene name); gtfD (gene name) |
Systematic name: |
sucrose:(1→6)-α-D-glucan 3(6)-α-D-glucosyltransferase |
Comments: |
The glucansucrases transfer a D-glucosyl residue from sucrose to a glucan chain. They are classified based on the linkage by which they attach the transferred residue. In some cases, in which the enzyme forms more than one linkage type, classification relies on the relative proportion of the linkages that are generated. This enzyme extends (1→6)-α-D-glucans by both α(1→3) and α(1→6) linkages, with one of the linkage types being dominant. cf. EC 2.4.1.140, alternansucrase. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 81725-87-3 |
References: |
1. |
Mukasa, H., Shimamura, A. and Tsumori, H. Purification and characterization of basic glucosyltransferase from Streptococcus mutans serotype c. Biochim. Biophys. Acta 719 (1982) 81–89. [DOI] [PMID: 6216919] |
2. |
Shimamura, A., Tsumori, H. and Mukasa, H. Purification and properties of Streptococcus mutans extracellular glucosyltransferase. Biochim. Biophys. Acta 702 (1982) 72–80. [DOI] [PMID: 6461359] |
3. |
Tsumori, H., Shimamura, A. and Mukasa, H. Purification and properties of extracellular glucosyltransferase synthesizing 1,6-, 1,3-α-D-glucan from Streptococcus mutans serotype a. J. Gen. Microbiol. 131 (1985) 3347–3353. [DOI] [PMID: 2937877] |
4. |
Fujiwara, T., Tamesada, M., Bian, Z., Kawabata, S., Kimura, S. and Hamada, S. Deletion and reintroduction of glucosyltransferase genes of Streptococcus mutans and role of their gene products in sucrose dependent cellular adherence. Microb Pathog 20 (1996) 225–233. [DOI] [PMID: 8737492] |
5. |
Monchois, V., Willemot, R.M. and Monsan, P. Glucansucrases: mechanism of action and structure-function relationships. FEMS Microbiol. Rev. 23 (1999) 131–151. [DOI] [PMID: 10234842] |
6. |
Ito, K., Ito, S., Shimamura, T., Weyand, S., Kawarasaki, Y., Misaka, T., Abe, K., Kobayashi, T., Cameron, A.D. and Iwata, S. Crystal structure of glucansucrase from the dental caries pathogen Streptococcus mutans. J. Mol. Biol. 408 (2011) 177–186. [DOI] [PMID: 21354427] |
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[EC 2.4.1.125 created 1984] |
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EC |
2.4.1.126 |
Accepted name: |
hydroxycinnamate 4-β-glucosyltransferase |
Reaction: |
UDP-glucose + trans-4-hydroxycinnamate = UDP + 4-O-β-D-glucosyl-4-hydroxycinnamate |
Other name(s): |
uridine diphosphoglucose-hydroxycinnamate glucosyltransferase; UDP-glucose-hydroxycinnamate glucosyltransferase; hydroxycinnamoyl glucosyltransferase |
Systematic name: |
UDP-glucose:trans-4-hydroxycinnamate 4-O-β-D-glucosyltransferase |
Comments: |
Acts on 4-coumarate, ferulate, caffeate and sinapate, forming a mixture of 4-glucosides and glucose esters (cf. EC 2.4.1.120 sinapate 1-glucosyltransferase). |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 77848-85-2 |
References: |
1. |
Fleuriet, A., Macheix, J.J., Suen, R. and Ibrahim, R.K. Partial purifiction and some properties of a hydroxycinnamoyl glucosyltransferase from tomato fruits. Z. Naturforsch. C: Biosci. 35 (1980) 967–972. |
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[EC 2.4.1.126 created 1984] |
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EC |
2.4.1.127 |
Accepted name: |
monoterpenol β-glucosyltransferase |
Reaction: |
UDP-glucose + (-)-menthol = UDP + (-)-menthyl O-β-D-glucoside |
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For diagram of menthol biosynthesis, click here |
Other name(s): |
uridine diphosphoglucose-monoterpenol glucosyltransferase; UDPglucose:monoterpenol glucosyltransferase |
Systematic name: |
UDP-glucose:(-)-menthol O-β-D-glucosyltransferase |
Comments: |
(+)-Neomenthol can also act as acceptor. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 78990-64-4 |
References: |
1. |
Fleuriet, A., Macheix, J.J., Suen, R. and Ibrahim, R.K. Partial purifiction and some properties of a hydroxycinnamoyl glucosyltransferase from tomato fruits. Z. Naturforsch. C: Biosci. 35 (1980) 967–972. |
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[EC 2.4.1.127 created 1984] |
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EC |
2.4.1.128 |
Accepted name: |
scopoletin glucosyltransferase |
Reaction: |
UDP-glucose + scopoletin = UDP + scopolin |
Other name(s): |
uridine diphosphoglucose-scopoletin glucosyltransferase; UDP-glucose:scopoletin glucosyltransferase; SGTase |
Systematic name: |
UDP-glucose:scopoletin O-β-D-glucosyltransferase |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 81210-69-7 |
References: |
1. |
Hino, F., Okazaki, M. and Miura, Y. Effect of 2,4-dichlorophenoxyacetic acid on glucosylation of scopoletin to scopolin in tobacco tissue-culture. Plant Physiol. 69 (1982) 810–813. [PMID: 16662301] |
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[EC 2.4.1.128 created 1984] |
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EC
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2.4.1.129
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Transferred entry: | peptidoglycan glycosyltransferase. Now EC 2.4.99.28, peptidoglycan glycosyltransferase
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[EC 2.4.1.129 created 1984, modified 2002, deleted 2023] |
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