ExplorEnz: EC 2.3.1.5*

Your query returned 11 entries. Printable version

2.3.1.5

Accepted name:

arylamine N-acetyltransferase

Reaction:

acetyl-CoA + an arylamine = CoA + an N-acetylarylamine

Other name(s):

arylamine acetylase; β-naphthylamine N-acetyltransferase; 4-aminobiphenyl N-acetyltransferase; acetyl CoA-arylamine N-acetyltransferase; 2-naphthylamine N-acetyltransferase; arylamine acetyltransferase; indoleamine N-acetyltransferase; N-acetyltransferase (ambiguous); p-aminosalicylate N-acetyltransferase; serotonin acetyltransferase; serotonin N-acetyltransferase

Systematic name:

acetyl-CoA:arylamine N-acetyltransferase

Comments:

Wide specificity for aromatic amines, including serotonin; also catalyses acetyl-transfer between arylamines without CoA.

Links to other databases:

BRENDA, EAWAG-BBD, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9027-33-2

References:

1.	Chou, T.C. and Lipmann, F. Separation of acetyl transfer enzymes in pigeon liver extract. J. Biol. Chem. 196 (1952) 89–103. [PMID: 12980945]
2.	Paul, R.C. and Ratledge, C. Further studies on anthranilate N-acetylanthranilic acid in Aerobacter aerogenes. Biochim. Biophys. Acta 320 (1973) 9–15. [DOI] [PMID: 4748369]
3.	Tabor, H., Mehler, A.H. and Stadtman, E.R. The enzymatic acetylation of amines. J. Biol. Chem. 204 (1953) 127–138. [PMID: 13084583]
4.	Weissbach, H., Redfield, B.G. and Axelrod, J. The enzymic acetylation of serotonin and other naturally occurring amines. Biochim. Biophys. Acta 54 (1961) 190–192. [DOI] [PMID: 14005907]

[EC 2.3.1.5 created 1961]

2.3.1.50

Accepted name:

serine C-palmitoyltransferase

Reaction:

palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO₂

Other name(s):

serine palmitoyltransferase; SPT; 3-oxosphinganine synthetase; acyl-CoA:serine C-2 acyltransferase decarboxylating

Systematic name:

palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)

Comments:

A pyridoxal-phosphate protein.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 62213-50-7

References:

1.	Brady, R.N., DiMari, S.J. and Snell, E.E. Biosynthesis of sphingolipid bases. 3. Isolation and characterization of ketonic intermediates in the synthesis of sphingosine and dihydrosphingosine by cell-free extracts of Hansenula ciferri. J. Biol. Chem. 244 (1969) 491–496. [PMID: 4388074]
2.	Stoffel, W., Le Kim, D. and Sticht, G. Biosynthesis of dihydrosphingosine in vitro. Hoppe-Seyler's Z. Physiol. Chem. 349 (1968) 664–670. [PMID: 4386961]

[EC 2.3.1.50 created 1976, modified 1982]

2.3.1.51

Accepted name:

1-acylglycerol-3-phosphate O-acyltransferase

Reaction:

acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate

Other name(s):

1-acyl-sn-glycero-3-phosphate acyltransferase; 1-acyl-sn-glycerol 3-phosphate acyltransferase; 1-acylglycero-3-phosphate acyltransferase; 1-acylglycerolphosphate acyltransferase; 1-acylglycerophosphate acyltransferase; lysophosphatidic acid-acyltransferase

Systematic name:

acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

Comments:

Acyl-[acyl-carrier protein] can also act as an acyl donor. The animal enzyme is specific for the transfer of unsaturated fatty acyl groups.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 51901-16-7

References:

1.	Frentzen, M., Heinz, E., McKeon, T.A. and Stumpf, P.K. Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts. Eur. J. Biochem. 129 (1983) 629–636. [DOI] [PMID: 6825679]
2.	Hill, E.E. and Lands, W.E.M. Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine. Biochim. Biophys. Acta 152 (1968) 645–648. [DOI] [PMID: 5661029]
3.	Yamashita, S., Hosaka, K. and Numa, S. Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes. Eur. J. Biochem. 38 (1973) 25–31. [DOI] [PMID: 4774123]

[EC 2.3.1.51 created 1976, modified 1990]

2.3.1.52

Accepted name:

2-acylglycerol-3-phosphate O-acyltransferase

Reaction:

acyl-CoA + 2-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate

Other name(s):

2-acylglycerophosphate acyltransferase

Systematic name:

acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase

Comments:

Saturated acyl-CoA thioesters are the most effective acyl donors.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 51901-17-8

References:

Yamashita, S., Hosaka, K. and Numa, S. Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes. Eur. J. Biochem. 38 (1973) 25–31. [DOI] [PMID: 4774123]

[EC 2.3.1.52 created 1976]

2.3.1.53

Accepted name:

phenylalanine N-acetyltransferase

Reaction:

acetyl-CoA + L-phenylalanine = CoA + N-acetyl-L-phenylalanine

Other name(s):

acetyl-CoA-L-phenylalanine α-N-acetyltransferase

Systematic name:

acetyl-CoA:L-phenylalanine N-acetyltransferase

Comments:

Also acts, more slowly, on L-histidine and L-alanine.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9075-16-5

References:

1.	Leuzinger, W., Baker, A.L. and Cauvin, E. Acetylcholinesterase. II. Crystallization, absorption spectra, isoionic point. Proc. Natl. Acad. Sci. USA 59 (1968) 620–623. [DOI] [PMID: 5238989]

[EC 2.3.1.53 created 1976]

2.3.1.54

Accepted name:

formate C-acetyltransferase

Reaction:

acetyl-CoA + formate = CoA + pyruvate

Other name(s):

pyruvate formate-lyase; pyruvic formate-lyase; formate acetyltransferase

Systematic name:

acetyl-CoA:formate C-acetyltransferase

Links to other databases:

BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9068-08-0

References:

1.	Knappe, J., Blaschkowski, H.P., Grobner, P. and Schmitt, T. Pyruvate formate-lyase of Escherichia coli: the acetyl-enzyme intermediate. Eur. J. Biochem. 50 (1974) 253–263. [DOI] [PMID: 4615902]

[EC 2.3.1.54 created 1976]

2.3.1.55

Deleted entry:

kanamycin 6′-N-acetyltransferase identical to EC 2.3.1.82 aminoglycoside N^6′-acetyltransferase

[EC 2.3.1.55 created 1976, deleted 1999]

2.3.1.56

Accepted name:

aromatic-hydroxylamine O-acetyltransferase

Reaction:

N-hydroxy-4-acetylaminobiphenyl + N-hydroxy-4-aminobiphenyl = N-hydroxy-4-aminobiphenyl + N-acetoxy-4-aminobiphenyl

Other name(s):

aromatic hydroxylamine acetyltransferase; arylhydroxamate acyltransferase; arylhydroxamate N,O-acetyltransferase; arylhydroxamic acid N,O-acetyltransferase; arylhydroxamic acyltransferase; N,O-acetyltransferase; N-hydroxy-2-acetylaminofluorene N-O acyltransferase

Systematic name:

N-hydroxy-4-acetylaminobiphenyl:N-hydroxy-4-aminobiphenyl O-acetyltransferase

Comments:

Transfers the N-acetyl group of some aromatic acethydroxamates to the O-position of some aromatic hydroxylamines.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 52660-15-8

References:

1.	Bartsch, H., Dworkin, C., Miller, E.C. and Miller, J.A. Formation of electrophilic N-acetoxyarylamines in cytosoles from rat mammary gland and other tissues by transacetylation from the carcinogen N-hydroxy-4-acetylaminobiphenyl. Biochim. Biophys. Acta 304 (1973) 42–55. [DOI] [PMID: 4699998]

[EC 2.3.1.56 created 1976]

2.3.1.57

Accepted name:

diamine N-acetyltransferase

Reaction:

acetyl-CoA + an alkane-α,ω-diamine = CoA + an N-acetyldiamine

Glossary:

spermidine = N-(3-aminopropyl)butane-1,4-diamine
spermine = N,N′-bis(3-aminopropyl)butane-1,4-diamine

Other name(s):

spermidine acetyltransferase; putrescine acetyltransferase; putrescine (diamine)-acetylating enzyme; diamine acetyltransferase; spermidine/spermine N¹-acetyltransferase; spermidine N¹-acetyltransferase; acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase; putrescine acetylase; putrescine N-acetyltransferase

Systematic name:

acetyl-CoA:alkane-α,ω-diamine N-acetyltransferase

Comments:

Acts on propane-1,3-diamine, pentane-1,5-diamine, putrescine, spermidine (forming N¹- and N⁸-acetylspermidine), spermine, N¹-acetylspermidine and N⁸-acetylspermidine.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 54596-36-0

References:

1.	Della Ragione, F. and Pegg, A.E. Purification and characterization of spermidine/spermine N¹-acetyltransferase from rat liver. Biochemistry 21 (1982) 6152–6158. [PMID: 7150547]

[EC 2.3.1.57 created 1976, modified 1989]

2.3.1.58

Accepted name:

2,3-diaminopropionate N-oxalyltransferase

Reaction:

oxalyl-CoA + L-2,3-diaminopropanoate = CoA + N³-oxalyl-L-2,3-diaminopropanoate

For diagram of O₃-Acetyl-L-serine metabolism, click here

Other name(s):

oxalyldiaminopropionate synthase; ODAP synthase; oxalyl-CoA:L-α,β-diaminopropionic acid oxalyltransferase; oxalyldiaminopropionic synthase; oxalyl-CoA:L-2,3-diaminopropanoate 3-N-oxalyltransferase

Systematic name:

oxalyl-CoA:L-2,3-diaminopropanoate N³-oxalyltransferase

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 62213-48-3

References:

1.	Malathi, K., Padmanaban, G. and Sarma, P.S. Biosynthesis of β-N-oxalyl-L-α,β-diaminopropionic acid, the Lathyrus sativus neurotoxin. Phytochemistry 9 (1970) 1603–1610.

[EC 2.3.1.58 created 1976]

2.3.1.59

Accepted name:

gentamicin 2′-N-acetyltransferase

Reaction:

acetyl-CoA + gentamicin C_1a = CoA + N^2′-acetylgentamicin C_1a

Glossary:

kanamycin

Other name(s):

gentamycin acetyltransferase II; gentamycin 2′-N-acetyltransferase; acetyl-CoA:gentamycin-C_1a N^2′-acetyltransferase

Systematic name:

acetyl-CoA:gentamicin-C_1a N^2′-acetyltransferase

Comments:

The antibiotics gentamicin A, sisomicin, tobramycin, paromomycin, neomycin B, kanamycin B and kanamycin C can also act as acceptors.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 50864-40-9

References:

1.	Benveniste, R. and Davies, J. Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proc. Natl. Acad. Sci. USA 70 (1973) 2276–2280. [DOI] [PMID: 4209515]

[EC 2.3.1.59 created 1976]