| EC |
2.3.1.82 |
| Accepted name: |
aminoglycoside 6′-N-acetyltransferase |
| Reaction: |
acetyl-CoA + kanamycin-B = CoA + N6′-acetylkanamycin-B |
| Glossary: |
kanamycin |
| Other name(s): |
aminoglycoside N6′-acetyltransferase; aminoglycoside-6′-acetyltransferase; aminoglycoside-6-N-acetyltransferase; kanamycin acetyltransferase |
| Systematic name: |
acetyl-CoA:kanamycin-B N6′-acetyltransferase |
| Comments: |
The antibiotics kanamycin A, kanamycin B, neomycin, gentamicin C1a, gentamicin C2 and sisomicin are substrates. The antibiotic tobramycin, but not paromomycin, can also act as acceptor. The 6-amino group of the purpurosamine ring is acetylated. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 56467-65-3 |
| References: |
| 1. |
le Goffic, F. and Martel, A. La résistance aux aminosides provoquée par une isoenzyme la kanamycine acétyltransférase. Biochimie 56 (1974) 893–897. [DOI] [PMID: 4614862] |
| 2. |
Benveniste, R. and Davies, J.E. Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor. Biochemistry 10 (1971) 1787–1796. [PMID: 4935296] |
| 3. |
Dowding, J.E. Mechanisms of gentamicin resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 11 (1977) 47–50. [PMID: 836013] |
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| [EC 2.3.1.82 created 1976 as EC 2.3.1.55, transferred 1999 to EC 2.3.1.82, modified 1999, modified 2015] |
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