The Enzyme Database

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EC 2.3.1.174     
Accepted name: 3-oxoadipyl-CoA thiolase
Reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA
For diagram of aerobic phenylacetate catabolism, click here and for diagram of benzoate metabolism, click here
Systematic name: succinyl-CoA:acetyl-CoA C-succinyltransferase
Comments: The enzyme from the bacterium Escherichia coli also has the activity of EC 2.3.1.223 (3-oxo-5,6-dehydrosuberyl-CoA thiolase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 403496-07-1
References:
1.  Kaschabek, S.R., Kuhn, B., Müller, D., Schmidt, E. and Reineke, W. Degradation of aromatics and chloroaromatics by Pseudomonas sp. strain B13: purification and characterization of 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase. J. Bacteriol. 184 (2002) 207–215. [PMID: 11741862]
2.  Gobel, M., Kassel-Cati, K., Schmidt, E. and Reineke, W. Degradation of aromatics and chloroaromatics by Pseudomonas sp. strain B13: cloning, characterization, and analysis of sequences encoding 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase. J. Bacteriol. 184 (2002) 216–223. [PMID: 11741863]
3.  Teufel, R., Mascaraque, V., Ismail, W., Voss, M., Perera, J., Eisenreich, W., Haehnel, W. and Fuchs, G. Bacterial phenylalanine and phenylacetate catabolic pathway revealed. Proc. Natl. Acad. Sci. USA 107 (2010) 14390–14395. [PMID: 20660314]
[EC 2.3.1.174 created 2005, modified 2013]
 
 


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