The Enzyme Database

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EC 2.3.1.162     
Accepted name: taxadien-5α-ol O-acetyltransferase
Reaction: acetyl-CoA + taxa-4(20),11-dien-5α-ol = CoA + taxa-4(20),11-dien-5α-yl acetate
For diagram of taxadiene biosynthesis, click here
Other name(s): acetyl coenzyme A:taxa-4(20),11(12)-dien-5α-ol O-acetyl transferase
Systematic name: acetyl-CoA:taxa-4(20),11-dien-5α-ol O-acetyltransferase
Comments: This is the third enzyme in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel), which is widely used in the treatment of carcinomas, sarcomas and melanomas.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 229032-29-5
References:
1.  Walker, K., Ketchum, R.E., Hezari, M., Gatfield, D., Goleniowski, M., Barthol, A. and Croteau, R. Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5α-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesis. Arch. Biochem. Biophys. 364 (1999) 273. [PMID: 10190984]
2.  Walker, K., Schoendorf, A. and Croteau, R. Molecular cloning of a taxa-4(20),11(12)-dien-5α-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. Arch. Biochem. Biophys. 374 (2000) 371–380. [PMID: 10666320]
[EC 2.3.1.162 created 2002]
 
 


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