| EC |
1.9.3.1 |
| Accepted name: |
cytochrome-c oxidase |
| Reaction: |
4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O |
| Other name(s): |
cytochrome oxidase; cytochrome a3; cytochrome aa3; Warburg’s respiratory enzyme; indophenol oxidase; indophenolase; complex IV (mitochondrial electron transport); ferrocytochrome c oxidase; NADH cytochrome c oxidase |
| Systematic name: |
ferrocytochrome-c:oxygen oxidoreductase |
| Comments: |
A cytochrome of the a type containing copper. The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment. Several bacteria appear to contain analogous oxidases. |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, METACYC, PDB, CAS registry number: 9001-16-5 |
| References: |
| 1. |
Keilin, D. and Hartree, E.F. Cytochrome oxidase. Proc. R. Soc. Lond. B Biol. Sci. 125 (1938) 171–186. |
| 2. |
Keilin, D. and Hartree, E.F. Cytochrome and cytochrome oxidase. Proc. R. Soc. Lond. B Biol. Sci. 127 (1939) 167–191. |
| 3. |
Wainio, W.W., Eichel, B. and Gould, A. Ion and pH optimum for the oxidation of ferrocytochrome c by cytochrome c oxidase in air. J. Biol. Chem. 235 (1960) 1521–1525. |
| 4. |
Yonetani, T. Studies on cytochrome oxidase. II. Steady state properties. J. Biol. Chem. 235 (1960) 3138–3243. [PMID: 13787372] |
| 5. |
Yonetani, T. Studies on cytochrome oxidase. III. Improved purification and some properties. J. Biol. Chem. 236 (1961) 1680–1688. [PMID: 13787373] |
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| [EC 1.9.3.1 created 1961, modified 2000] |
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