The Enzyme Database

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EC 1.3.1.34     
Accepted name: 2,4-dienoyl-CoA reductase (NADPH)
Reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+
Other name(s): 4-enoyl-CoA reductase (NADPH2); 4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase; 4-enoyl-CoA reductase; 2,4-dienoyl-CoA reductase (NADPH2)
Systematic name: trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase
Comments: Best substrates for reduction contain a 2,4-diene structure with a chain-length of 8 or 10
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 82869-38-3
References:
1.  Dommes, V., Luster, W., Cvetanovic, M. and Kunau, W.-H. Purification by affinity chromatography of 2,4-dienoyl-CoA reductases from bovine liver and Escherichia coli. Eur. J. Biochem. 125 (1982) 335–341. [PMID: 6749495]
2.  Kunau, W.-H. and Dommes, P. Degradation of unsaturated fatty acids. Identification of intermediates in the degradation of cis-4-decenoly-CoA by extracts of beef-liver mitochondria. Eur. J. Biochem. 91 (1978) 533–544. [PMID: 729581]
[EC 1.3.1.34 created 1984, modified 1986]
 
 


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