| EC |
1.3.1.34 |
| Accepted name: |
2,4-dienoyl-CoA reductase (NADPH) |
| Reaction: |
trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+ |
| Other name(s): |
4-enoyl-CoA reductase (NADPH2); 4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase; 4-enoyl-CoA reductase; 2,4-dienoyl-CoA reductase (NADPH2) |
| Systematic name: |
trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase |
| Comments: |
Best substrates for reduction contain a 2,4-diene structure with a chain-length of 8 or 10 |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 82869-38-3 |
| References: |
| 1. |
Dommes, V., Luster, W., Cvetanovic, M. and Kunau, W.-H. Purification by affinity chromatography of 2,4-dienoyl-CoA reductases from bovine liver and Escherichia coli. Eur. J. Biochem. 125 (1982) 335–341. [DOI] [PMID: 6749495] |
| 2. |
Kunau, W.-H. and Dommes, P. Degradation of unsaturated fatty acids. Identification of intermediates in the degradation of cis-4-decenoly-CoA by extracts of beef-liver mitochondria. Eur. J. Biochem. 91 (1978) 533–544. [DOI] [PMID: 729581] |
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| [EC 1.3.1.34 created 1984, modified 1986] |
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