This enzyme participates in the degradation of glutamate and 4-aminobutyrate.
It is similar to EC 22.214.171.124 [succinate-semialdehyde dehydrogenase (NAD+)], and EC 126.96.36.199 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NADP+. The enzyme from Escherichia coli is 20-fold more active with NADP+ than NAD+ .
Bartsch, K., von Johnn-Marteville, A. and Schulz, A. Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate:succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD). J. Bacteriol.172 (1990) 7035–7042. [DOI] [PMID: 2254272]
Jaeger, M., Rothacker, B. and Ilg, T. Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases. Biochem. Biophys. Res. Commun.372 (2008) 400–406. [DOI] [PMID: 18474219]