The Enzyme Database

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EC 1.16.8.1     
Accepted name: cob(II)yrinic acid a,c-diamide reductase
Reaction: 2 cob(I)yrinic acid a,c-diamide + FMN + 2 H+ = 2 cob(II)yrinic acid a,c-diamide + FMNH2
For diagram of corrin biosynthesis (part 4), click here
Other name(s): cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase (incorrect)
Systematic name: cob(I)yrinic acid-a,c-diamide:FMN oxidoreductase
Comments: This enzyme also catalyses the reduction of cob(II)yric acid, cob(II)inamide, cob(II)inamide phosphate, GDP-cob(II)inamide and cob(II)alamin although cob(II)yrinic acid a,c-diamide is thought to be the physiological substrate [1]. Also uses FAD and NADH but not NADPH.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 145539-93-1
References:
1.  Blanche, F., Maton, L., Debussche, L. and Thibaut, D. Purification and characterization of cob(II)yrinic acid a,c-diamide reductase from Pseudomonas denitrificans. J. Bacteriol. 174 (1992) 7452–7454. [PMID: 1429467]
2.  Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. The biosynthesis of adenosylcobalamin (vitamin B12). Nat. Prod. Rep. 19 (2002) 390–412. [PMID: 12195810]
[EC 1.16.8.1 created 2004]
 
 


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