| EC |
1.1.1.37 |
| Accepted name: |
malate dehydrogenase |
| Reaction: |
(S)-malate + NAD+ = oxaloacetate + NADH + H+ |
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For diagram of the citric-acid cycle, click here and for diagram of the glyoxylate cycle, click here |
| Other name(s): |
malic dehydrogenase; L-malate dehydrogenase; NAD-L-malate dehydrogenase; malic acid dehydrogenase; NAD-dependent malic dehydrogenase; NAD-malate dehydrogenase; NAD-malic dehydrogenase; malate (NAD) dehydrogenase; NAD-dependent malate dehydrogenase; NAD-specific malate dehydrogenase; NAD-linked malate dehydrogenase; MDH; L-malate-NAD+ oxidoreductase |
| Systematic name: |
(S)-malate:NAD+ oxidoreductase |
| Comments: |
Also oxidizes some other 2-hydroxydicarboxylic acids. |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, METACYC, PDB, CAS registry number: 9001-64-3 |
| References: |
| 1. |
Banaszak, L.J. and Bradshaw, R.A. Malate dehydrogenase. In: Boyer, P.D. (Ed.), The Enzymes, 3rd edn, vol. 11, Academic Press, New York, 1975, pp. 369–396. |
| 2. |
Guha, A., Englard, S. and Listowsky, I. Beef heart malic dehydrogenases. VII. Reactivity of sulfhydryl groups and conformation of the supernatant enzyme. J. Biol. Chem. 243 (1968) 609–615. [PMID: 5637713] |
| 3. |
McReynolds, M.S. and Kitto, G.B. Purification and properties of Drosophila malate dehydrogenases. Biochim. Biophys. Acta 198 (1970) 165–175. [PMID: 4313528] |
| 4. |
Wolfe, R.G. and Nielands, J.B. Some molecular and kinetic properties of heart malic dehydrogenase. J. Biol. Chem. 221 (1956) 61–69. [PMID: 13345798] |
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| [EC 1.1.1.37 created 1961] |
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