EC |
1.1.1.299 |
Accepted name: |
malate dehydrogenase [NAD(P)+] |
Reaction: |
(S)-malate + NAD(P)+ = oxaloacetate + NAD(P)H + H+ |
Other name(s): |
MdH II, NAD(P)+-dependent malate dehyrogenase |
Systematic name: |
(S)-malate:NAD(P)+ oxidoreductase |
Comments: |
This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyses only the reduction of oxaloacetate, and can use NAD+ and NADP+ with similar specific activity [1].
Different from EC 1.1.1.37 (malate dehydrogenase (NAD+)), EC 1.1.1.82 (malate dehydrogenase (NADP+)) and EC 1.1.5.4 (malate dehydrogenase (quinone)). |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Thompson, H., Tersteegen, A., Thauer, R.K. and Hedderich, R. Two malate dehydrogenases in Methanobacterium thermoautotrophicum. Arch. Microbiol. 170 (1998) 38–42. [PMID: 9639601] |
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[EC 1.1.1.299 created 2009] |
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