The Enzyme Database

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Accepted name: trans-resveratrol di-O-methyltransferase
Reaction: 2 S-adenosyl-L-methionine + trans-resveratrol = 2 S-adenosyl-L-homocysteine + pterostilbene (overall reaction)
(1a) S-adenosyl-L-methionine + trans-resveratrol = S-adenosyl-L-homocysteine + 3-methoxy-4′,5-dihydroxy-trans-stilbene
(1b) S-adenosyl-L-methionine + 3-methoxy-4′,5-dihydroxy-trans-stilbene = S-adenosyl-L-homocysteine + pterostilbene
For diagram of chalcone and stilbene biosynthesis, click here
Glossary: 3-methoxy-4′,5-dihydroxy-trans-stilbene = resveratrol monomethyl ether
pterostilbene = 3,5-dimethoxy-4′-hydroxy-trans-stilbene
trans-resveratrol = 3,4′,5-trihydroxy-trans-stilbene
Other name(s): ROMT; resveratrol O-methyltransferase; pterostilbene synthase
Systematic name: S-adenosyl-L-methionine:trans-resveratrol 3,5-O-dimethyltransferase
Comments: The enzyme catalyses the biosynthesis of pterostilbene from resveratrol.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Schmidlin, L., Poutaraud, A., Claudel, P., Mestre, P., Prado, E., Santos-Rosa, M., Wiedemann-Merdinoglu, S., Karst, F., Merdinoglu, D. and Hugueney, P. A stress-inducible resveratrol O-methyltransferase involved in the biosynthesis of pterostilbene in grapevine. Plant Physiol. 148 (2008) 1630–1639. [DOI] [PMID: 18799660]
[EC created 2012]
Accepted name: trihydroxystilbene synthase
Reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + trans-resveratrol + 4 CO2
For diagram of chalcone and stilbene biosynthesis, click here
Glossary: trans-resveratrol = 3,4′,5-trihydroxy-trans-stilbene
Other name(s): resveratrol synthase; stilbene synthase (ambiguous)
Systematic name: malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Comments: Not identical with EC naringenin-chalcone synthase or EC pinosylvin synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 128449-70-7
1.  Schöppner, A. and Kindl, H. Purification and properties of a stilbene synthase from induced cell suspension cultures of peanut. J. Biol. Chem. 259 (1984) 6806–6811. [PMID: 6427224]
[EC created 1989]

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