| EC |
2.3.1.74 |
| Accepted name: |
chalcone synthase |
| Reaction: |
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2 |
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For diagram of chalcone and stilbene biosynthesis, click here |
| Glossary: |
phloretin = 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one |
| Other name(s): |
naringenin-chalcone synthase; flavanone synthase; 6′-deoxychalcone synthase; chalcone synthetase; DOCS; CHS |
| Systematic name: |
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing) |
| Comments: |
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 56803-04-4 |
| References: |
| 1. |
Ayabe, S.-I., Udagawa, A. and Furuya, T. NAD(P)H-dependent 6′-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract. Arch. Biochem. Biophys. 261 (1988) 458–462. [DOI] [PMID: 3355160] |
| 2. |
Heller, W. and Hahlbrock, K. Highly purified "flavanone synthase" from parsley catalyzes the formation of naringenin chalcone. Arch. Biochem. Biophys. 200 (1980) 617–619. [DOI] [PMID: 7436427] |
| 3. |
Yahyaa, M., Ali, S., Davidovich-Rikanati, R., Ibdah, M., Shachtier, A., Eyal, Y., Lewinsohn, E. and Ibdah, M. Characterization of three chalcone synthase-like genes from apple (Malus x domestica Borkh.). Phytochemistry 140 (2017) 125–133. [DOI] [PMID: 28482241] |
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| [EC 2.3.1.74 created 1984, modified 2018] |
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