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Your query returned 1 entry. Printable version
EC | 5.5.1.23 | ||||||
Accepted name: | aklanonic acid methyl ester cyclase | ||||||
Reaction: | aklaviketone = methyl aklanonate | ||||||
For diagram of aklavinone biosynthesis, click here | |||||||
Glossary: | aklaviketone = methyl (1R,2R)-2-ethyl-2,5,7-trihydroxy-4,6,11-trioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate methyl aklanonate = methyl [4,5-dihydroxy-9,10-dioxo-3-(3-oxopentanoyl)-9,10-dihydroanthracen-2-yl]acetate |
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Other name(s): | dauD (gene name); aknH (gene name); dnrD (gene name); methyl aklanonate cyclase; methyl aklanonate-aklaviketone isomerase (cyclizing); aklaviketone lyase (decyclizing) | ||||||
Systematic name: | aklaviketone lyase (ring-opening) | ||||||
Comments: | The enzyme is involved in the biosynthesis of aklaviketone, an intermediate in the biosynthetic pathways leading to formation of several anthracycline antibiotics, including aclacinomycin, daunorubicin and doxorubicin. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||
References: |
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