EC |
4.3.1.4 |
Accepted name: |
formimidoyltetrahydrofolate cyclodeaminase |
Reaction: |
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3 |
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For diagram of folate cofactors, click here and for diagram of C1 metabolism, click here |
Other name(s): |
formiminotetrahydrofolate cyclodeaminase; 5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing) |
Systematic name: |
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming) |
Comments: |
In eukaroytes, occurs as a bifunctional enzyme that also has glutamate formimidoyltransferase (EC 2.1.2.5) activity. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9032-05-7 |
References: |
1. |
Rabinowitz, J.C. and Pricer, W.E. Formiminotetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N10-formyltetrahydrofolic acid. J. Am. Chem. Soc. 78 (1956) 5702–5704. |
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[EC 4.3.1.4 created 1961, modified 2000] |
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