| EC |
4.1.3.4 |
| Accepted name: |
hydroxymethylglutaryl-CoA lyase |
| Reaction: |
(S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate |
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For diagram of mevalonate biosynthesis, click here |
| Other name(s): |
hydroxymethylglutaryl coenzyme A-cleaving enzyme; hydroxymethylglutaryl coenzyme A lyase; 3-hydroxy-3-methylglutaryl coenzyme A lyase; 3-hydroxy-3-methylglutaryl CoA cleaving enzyme; 3-hydroxy-3-methylglutaryl-CoA lyase; (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase |
| Systematic name: |
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming) |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9030-83-5 |
| References: |
| 1. |
Bachhawat, B.K., Robinson, W.G. and Coon, M.J. The enzymatic cleavage of β-hydroxy-β-methylglutaryl coenzyme A to acetoacetate and acetyl coenzyme A. J. Biol. Chem. 216 (1955) 727–736. [PMID: 13271348] |
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| [EC 4.1.3.4 created 1961] |
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