| EC |
3.2.2.21 |
| Accepted name: |
DNA-3-methyladenine glycosylase II |
| Reaction: |
Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine |
| Other name(s): |
deoxyribonucleate 3-methyladenine glycosidase II; 3-methyladenine DNA glycosylase II; DNA-3-methyladenine glycosidase II; AlkA |
| Systematic name: |
alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine) |
| Comments: |
Involved in the removal of alkylated bases from DNA in Escherichia coli (cf. EC 2.1.1.63 methylated-DNA—[protein]-cysteine S-methyltransferase). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 89287-38-7 |
| References: |
| 1. |
Evensen, G. and Seeberg, E. Adaptation to alkylation resistance involves the induction of a DNA glycosylase. Nature 296 (1982) 773–775. [PMID: 7040984] |
| 2. |
Karran, P., Hjelmgren, T. and Lindahl, T. Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents. Nature 296 (1982) 770–773. [PMID: 7040983] |
| 3. |
Riazuddin, S. and Lindahl, T. Properties of 3-methyladenine-DNA glycosylase from Escherichia coli. Biochemistry 17 (1978) 2110–2118. [PMID: 352392] |
| 4. |
Thomas, L., Yang, C.-H. and Goldthwait, D.A. Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine. Biochemistry 21 (1982) 1162–1169. [PMID: 7041972] |
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| [EC 3.2.2.21 created 1990, modified 2000] |
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