ExplorEnz: EC 3.1.3.75

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3.1.3.75

Accepted name:

phosphoethanolamine/phosphocholine phosphatase

Reaction:

(1) O-phosphoethanolamine + H₂O = ethanolamine + phosphate
(2) phosphocholine + H₂O = choline + phosphate

Other name(s):

PHOSPHO1; 3X11A

Systematic name:

phosphoethanolamine phosphohydrolase

Comments:

Requires active site Mg²⁺ but also works, to a lesser extent, with Co²⁺ and Mn²⁺. The enzyme is highly specific for phosphoethanolamine and phosphocholine.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Houston, B., Seawright, E., Jefferies, D., Hoogland, E., Lester, D., Whitehead, C. and Farquharson, C. Identification and cloning of a novel phosphatase expressed at high levels in differentiating growth plate chondrocytes. Biochim. Biophys. Acta 1448 (1999) 500–506. [DOI] [PMID: 9990301]
2.	Stewart, A.J., Schmid, R., Blindauer, C.A., Paisey, S.J. and Farquharson, C. Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily. Protein Eng. 16 (2003) 889–895. [DOI] [PMID: 14983068]
3.	Roberts, S.J., Stewart, A.J., Sadler, P.J. and Farquharson, C. Human PHOSPHO1 displays high specific phosphoethanolamine and phosphocholine phosphatase activities. Biochem. J. 382 (2004) 59–65. [DOI] [PMID: 15175005]

[EC 3.1.3.75 created 2004]