Accepted name: phosphoethanolamine/phosphocholine phosphatase
Reaction: (1) O-phosphoethanolamine + H2O = ethanolamine + phosphate
(2) phosphocholine + H2O = choline + phosphate
Other name(s): PHOSPHO1; 3X11A
Systematic name: phosphoethanolamine phosphohydrolase
Comments: Requires active site Mg2+ but also works, to a lesser extent, with Co2+ and Mn2+. The enzyme is highly specific for phosphoethanolamine and phosphocholine.
1.  Houston, B., Seawright, E., Jefferies, D., Hoogland, E., Lester, D., Whitehead, C. and Farquharson, C. Identification and cloning of a novel phosphatase expressed at high levels in differentiating growth plate chondrocytes. Biochim. Biophys. Acta 1448 (1999) 500–506. [PMID: 9990301]
2.  Stewart, A.J., Schmid, R., Blindauer, C.A., Paisey, S.J. and Farquharson, C. Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily. Protein Eng. 16 (2003) 889–895. [PMID: 14983068]
3.  Roberts, S.J., Stewart, A.J., Sadler, P.J. and Farquharson, C. Human PHOSPHO1 displays high specific phosphoethanolamine and phosphocholine phosphatase activities. Biochem. J. 382 (2004) 59–65. [PMID: 15175005]
[EC created 2004]