| EC |
3.1.3.62 |
| Accepted name: |
multiple inositol-polyphosphate phosphatase |
| Reaction: |
myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate |
| Other name(s): |
inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase; inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase; inositol tetrakisphosphate phosphomonoesterase; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase; MIPP |
| Systematic name: |
1D-myo-inositol-hexakisphosphate 5-phosphohydrolase |
| Comments: |
This enzyme exists in two isoforms. It also acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 116958-30-6 |
| References: |
| 1. |
Cullen, P.J., Irvine, R.F., Drøbak, B.J. and Dawson, A.P. Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate. Biochem. J. 259 (1989) 931–933. [PMID: 2786415] |
| 2. |
Craxton, A., Caffrey, J.J., Burkhart, W., Safrany, S.T. and Shears, S.B. Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase. Biochem. J. 328 (1997) 75–81. [PMID: 9359836] |
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| [EC 3.1.3.62 created 1992, modified 2002] |
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