The Enzyme Database

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Accepted name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
Reaction: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate
For diagram of 1-phosphatidyl-myo-inositol metabolism (part 2), click here
Glossary: inositol 1,4,5-trisphosphate = Ins(1,4,5)P3
inositol 1,3,4,5-tetrakisphosphate = Ins(1,3,4,5)P4
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3
Other name(s): PTEN; MMAC1; phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase
Systematic name: 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase
Comments: Requires Mg2+. Does not dephosphorylate inositol 4,5-bisphosphate. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4,5)P4 to Ins(1,4,5)P3
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 210488-47-4
1.  Kabuyama, Y., Nakatsu, N., Homma, Y., Fukui, Y. Purification and characterization of phosphatidyl inositol-3,4,5-trisphosphate phosphatase in bovine thymus. Eur. J. Biochem. 238 (1996) 350–356. [DOI] [PMID: 8681945]
2.  Maehama, T. and Dixon, J.E. The tumor suppressor, PTEN /MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273 (1998) 13375–13378. [DOI] [PMID: 9593664]
[EC created 1999, modified 2002]

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