| EC |
2.7.11.16 |
| Accepted name: |
G-protein-coupled receptor kinase |
| Reaction: |
ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate |
| Other name(s): |
G protein-coupled receptor kinase; GPCR kinase; GPCRK; GRK4; GRK5; GRK6; STK16 |
| Systematic name: |
ATP:[G-protein-coupled receptor] phosphotransferase |
| Comments: |
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate. (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.15, β-adrenergic-receptor kinase). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Kunapuli, P., Onorato, J.J., Hosey, M.M. and Benovic, J.L. Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5. J. Biol. Chem. 269 (1994) 1099–1105. [PMID: 8288567] |
| 2. |
Premont, R.T., Koch, W.J., Inglese, J. and Lefkowitz, R.J. Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. J. Biol. Chem. 269 (1994) 6832–6841. [PMID: 8120045] |
| 3. |
Willets, J.M., Challiss, R.A. and Nahorski, S.R. Non-visual GRKs: are we seeing the whole picture? Trends Pharmacol. Sci. 24 (2003) 626–633. [DOI] [PMID: 14654303] |
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| [EC 2.7.11.16 created 2005] |
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