| EC |
2.2.1.8 |
| Accepted name: |
fluorothreonine transaldolase |
| Reaction: |
L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine |
| Systematic name: |
fluoroacetaldehyde:L-threonine aldehydetransferase |
| Comments: |
A pyridoxal phosphate protein. Can also convert chloroacetaldehyde into4-chloro-L-threonine. Unlike EC 2.1.2.1, glycine hydroxymethyltransferase, does not use glycine as a substrate. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 403503-13-9 |
| References: |
| 1. |
Murphy, C.D., O'Hagan, D. and Schaffrath, C. Identification of a PLP-dependent threonine transaldolase: a novel enzyme involved in 4-fluorothreonine biosynthesis in Streptomyces cattleya. Angew. Chem. Int. Ed. Engl. 40 (2001) 4479–4481. [DOI] [PMID: 12404452] |
| 2. |
Murphy, C.D., Schaffrath, C. and O'Hagan, D. Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya. Chemosphere 52 (2003) 455–461. [DOI] [PMID: 12738270] |
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| [EC 2.2.1.8 created 2003] |
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