The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

Accepted name: glycine hydroxymethyltransferase
Reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
For diagram of folate cofactors, click here and for diagram of C1 metabolism, click here
Other name(s): serine aldolase; threonine aldolase; serine hydroxymethylase; serine hydroxymethyltransferase; allothreonine aldolase; L-serine hydroxymethyltransferase; L-threonine aldolase; serine transhydroxymethylase
Systematic name: 5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase
Comments: A pyridoxal-phosphate protein. Also catalyses the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy-N6,N6,N6-trimethyl-L-lysine.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9029-83-8
1.  Akhtar, M. and El-Obeid, H.A. Inactivation of serine transhydroxymethylase and threonine aldolase activities. Biochim. Biophys. Acta 258 (1972) 791–799. [DOI] [PMID: 5017703]
2.  Blakley, R.L. A spectrophotometric study of the reaction catalysed by serine transhydroxymethylase. Biochem. J. 77 (1960) 459–465. [PMID: 16748851]
3.  Fujioka, M. Purification and properties of serine hydroxymethylase from soluble and mitochondrial fractions of rabbit liver. Biochim. Biophys. Acta 185 (1969) 338–349. [DOI] [PMID: 5808700]
4.  Kumagai, H., Nagate, T., Yoshida, H. and Yamada, H. Threonine aldolase from Candida humicola. II. Purification, crystallization and properties. Biochim. Biophys. Acta 258 (1972) 779–790. [DOI] [PMID: 5017702]
5.  Schirch, L.V. and Gross, T. Serine transhydroxymethylase. Identification as the threonine and allothreonine aldolases. J. Biol. Chem. 243 (1968) 5651–5655. [PMID: 5699057]
[EC created 1961, modified 1983]

Data © 2001–2024 IUBMB
Web site © 2005–2024 Andrew McDonald