| EC |
2.1.1.161 |
| Accepted name: |
dimethylglycine N-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine |
| Glossary: |
betaine = glycine betaine = N,N,N-trimethylglycine = N,N,N-trimethylammonioacetate |
| Other name(s): |
BsmB; DMT |
| Systematic name: |
S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase (betaine-forming) |
| Comments: |
This enzyme, from the marine cyanobacterium Synechococcus sp. WH8102, differs from EC 2.1.1.157, sarcosine/dimethylglycine N-methyltransferase in that it cannot use sarcosine as an alternative substrate [1]. Betaine is a ’compatible solute’ that enables cyanobacteria to cope with osmotic stress by maintaining a positive cellular turgor. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Lu, W.D., Chi, Z.M. and Su, C.D. Identification of glycine betaine as compatible solute in Synechococcus sp. WH8102 and characterization of its N-methyltransferase genes involved in betaine synthesis. Arch. Microbiol. 186 (2006) 495–506. [DOI] [PMID: 17019606] |
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| [EC 2.1.1.161 created 2007] |
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