|
Your query returned 1 entry. Printable version
EC | 2.1.1.157 | ||||||
Accepted name: | sarcosine/dimethylglycine N-methyltransferase | ||||||
Reaction: | 2 S-adenosyl-L-methionine + sarcosine = 2 S-adenosyl-L-homocysteine + betaine (overall reaction) (1a) S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine (1b) S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine |
||||||
Glossary: | sarcosine = N-methylglycine betaine = glycine betaine = N,N,N-trimethylglycine = N,N,N-trimethylammonioacetate |
||||||
Other name(s): | ApDMT; sarcosine-dimethylglycine methyltransferase; SDMT; sarcosine dimethylglycine N-methyltransferase; S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase | ||||||
Systematic name: | S-adenosyl-L-methionine:sarcosine(or N,N-dimethylglycine) N-methyltransferase [N,N-dimethylglycine(or betaine)-forming] | ||||||
Comments: | Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process. The first enzyme, EC 2.1.1.156, glycine/sarcosine N-methyltransferase, leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of this enzyme. Both of these enzymes can catalyse the formation of N,N-dimethylglycine from sarcosine [3]. The reactions are strongly inhibited by S-adenosyl-L-homocysteine. | ||||||
Links to other databases: | BRENDA, EXPASY, Gene, KEGG, MetaCyc | ||||||
References: |
| ||||||