| EC |
1.5.1.56 |
| Accepted name: |
3,17-didehydrostemmadenine reductase |
| Reaction: |
17-dehydrostemmadenine + NADP+ = 3,17-didehydrostemmadenine + NADPH + H+ |
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For diagram of biosythesis of stemmadenine and related alkaloids, click here |
| Glossary: |
3,17-didehydrostemmadenine = 3,4-didehydro-17-dehydrostemmadenine |
| Other name(s): |
Redox1 |
| Systematic name: |
17-dehydrostemmadenine:NADP+ 3(4)-oxidoreductase |
| Comments: |
The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a biosynthetic pathway that leads to production of the bisindole alkaloid compounds vinblastine and vincristine, which are used as anticancer drugs. Both the substrate and the product of the enzyme are unstable. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Qu, Y., Easson, M.EA.M., Simionescu, R., Hajicek, J., Thamm, A.MK., Salim, V. and De Luca, V. Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine. Proc. Natl. Acad. Sci. USA 115 (2018) 3180–3185. [DOI] [PMID: 29511102] |
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| [EC 1.5.1.56 created 2024] |
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