|
|
Your query returned 1 entry. 
Printable version
| EC | 1.14.19.80 | ||||||
| Accepted name: | (19E)-geissoschizine oxidase | ||||||
| Reaction: | (19E)-geissoschizine + O2 + [reduced NADPH-hemoprotein reductase] = akuammicine + formate + H2O + [oxidized NADPH-hemoprotein reductase] (overall reaction) (1a) (19E)-geissoschizine + O2 + [reduced NADPH-hemoprotein reductase] = 3,17-didehydrostemmadenine + 2 H2O + [oxidized NADPH-hemoprotein reductase] (1b) 3,17-didehydrostemmadenine = 17-dehydropreakuammicine (spontaneous) (1c) 17-dehydropreakuammicine + H2O = 17-dehydropreakuammicine hydrate (spontaneous) (1d) 17-dehydropreakuammicine hydrate = akuammicine + formate (spontaneous) |
||||||
| For diagram of biosythesis of stemmadenine and related alkaloids, click here | |||||||
| Glossary: | (19E)-geissoschizine = methyl (16ξ,19E)-16-formylcoryn-19-en-17-oate | ||||||
| Other name(s): | GO (gene name); CYP71D1V1 (gene name) | ||||||
| Systematic name: | (19E)-geissoschizine,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (akuammicine-forming) | ||||||
| Comments: | A cytochrome P-450 (heme-thiolate) enzyme characterized from the plant Catharanthus roseus (Madagascar periwinkle), that participates in the biosynthesis of a number of monoterpene alkaloids, as well as the bisindole alkaloids vinblastine and vincristine. The enzyme generates a nine-carbon ring that contains a nitrogen atom. The direct product of the enzyme, 3,17-didehydrostemmadenine, is unstable, and in the absence of other enzymes becomes akuammicine non-enzymically. However, in the presence of two dehydrogenases it is converted to stemmadenine via 17-dehydrostemmadenine. | ||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
| References: |
| ||||||