| EC |
1.14.14.90 |
| Accepted name: |
isoflavone 2′-hydroxylase |
| Reaction: |
an isoflavone + [reduced NADPH—hemoprotein reductase] + O2 = a 2′-hydroxyisoflavone + [oxidized NADPH—hemoprotein reductase] + H2O |
|
For diagram of the biosynthesis of formononetin and derivatives, click here |
| Other name(s): |
isoflavone 2′-monooxygenase; CYP81E1; CYP Ge-3 |
| Systematic name: |
isoflavone,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (2′-hydroxylating) |
| Comments: |
A cytochrome P-450 (heme-thiolate) protein. Acts on daidzein, formononetin and genistein. EC 1.14.14.89, 4′-methoxyisoflavone 2′-hydroxylase, has the same reaction but is more specific as it requires a 4′-methoxyisoflavone. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 110183-49-8 |
| References: |
| 1. |
Akashi, T., Aoki, T. and Ayabe, S.-I. CYP81E1, a cytochrome P450 cDNA of licorice (Glycyrrhiza echinata L.), encodes isoflavone 2′-hydroxylase. Biochem. Biophys. Res. Commun. 251 (1998) 67–70. [DOI] [PMID: 9790908] |
|
| [EC 1.14.14.90 created 2005 as EC 1.14.13.89, transferred 2018 to EC 1.14.14.90] |
| |
|
| |
|
Printable version