| EC |
1.14.13.113 |
| Accepted name: |
FAD-dependent urate hydroxylase |
| Reaction: |
urate + NADH + H+ + O2 = 5-hydroxyisourate + NAD+ + H2O |
| Other name(s): |
HpxO enzyme; FAD-dependent urate oxidase; urate hydroxylase |
| Systematic name: |
urate,NADH:oxygen oxidoreductase (5-hydroxyisourate-forming) |
| Comments: |
A flavoprotein. The reaction is part of the purine catabolic pathway in the bacterium Klebsiella pneumoniae. The enzyme is different from EC 1.7.3.3, factor-independent urate hydroxylase, found in most plants, which produces hydrogen peroxide. The product of the enzyme is a substrate for EC 3.5.2.17, hydroxyisourate hydrolase. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
O'Leary, S.E., Hicks, K.A., Ealick, S.E. and Begley, T.P. Biochemical characterization of the HpxO enzyme from Klebsiella pneumoniae, a novel FAD-dependent urate oxidase. Biochemistry 48 (2009) 3033–3035. [DOI] [PMID: 19260710] |
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| [EC 1.14.13.113 created 2010] |
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