| EC |
1.1.1.52 |
| Accepted name: |
3α-hydroxycholanate dehydrogenase (NAD+) |
| Reaction: |
lithocholate + NAD+ = 3-oxo-5β-cholan-24-oate + NADH + H+ |
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For diagram of cholesterol catabolism (rings A, B and C), click here |
| Glossary: |
lithocholate = 3α-hydroxy-5β-cholan-24-oate |
| Other name(s): |
α-hydroxy-cholanate dehydrogenase; lithocholate:NAD+ oxidoreductase; 3α-hydroxycholanate dehydrogenase |
| Systematic name: |
lithocholate:NAD+ 3-oxidoreductase |
| Comments: |
Also acts on other 3α-hydroxysteroids with an acidic side-chain. cf. EC 1.1.1.392, 3α-hydroxycholanate dehydrogenase (NADP+). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9028-57-3 |
| References: |
| 1. |
Hayaishi, O., Saito, Y., Jakoby, W.B. and Stohlman, E.F. Reversible enzymatic oxidation of bile acids. Arch. Biochem. Biophys. 56 (1955) 554–555. [DOI] [PMID: 14377608] |
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| [EC 1.1.1.52 created 1961, modified 1976, modified 2016] |
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