| EC |
1.1.1.392 |
| Accepted name: |
3α-hydroxycholanate dehydrogenase (NADP+) |
| Reaction: |
lithocholate + NADP+ = 3-oxo-5β-cholan-24-oate + NADPH + H+ |
| Glossary: |
lithocholate = 3α-hydroxy-5β-cholan-24-oate |
| Other name(s): |
α-hydroxy-cholanate dehydrogenase (ambiguous) |
| Systematic name: |
lithocholate:NADP+ 3-oxidoreductase |
| Comments: |
This bacterial enzyme is involved in the modification of secondary bile acids to form 3β-bile acids (also known as iso-bile acids) via a 3-oxo intermediate. The enzyme catalyses a reversible reaction in vitro. Also acts on related bile acids. cf. EC 1.1.1.52, 3α-hydroxycholanate dehydrogenase (NAD+). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9028-57-3 |
| References: |
| 1. |
Devlin, A.S. and Fischbach, M.A. A biosynthetic pathway for a prominent class of microbiota-derived bile acids. Nat. Chem. Biol. 11 (2015) 685–690. [DOI] [PMID: 26192599] |
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| [EC 1.1.1.392 created 2016] |
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