The Enzyme Database

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Accepted name: 3α-hydroxycholanate dehydrogenase (NADP+)
Reaction: lithocholate + NADP+ = 3-oxo-5β-cholan-24-oate + NADPH + H+
Glossary: lithocholate = 3α-hydroxy-5β-cholan-24-oate
Other name(s): α-hydroxy-cholanate dehydrogenase (ambiguous)
Systematic name: lithocholate:NADP+ 3-oxidoreductase
Comments: This bacterial enzyme is involved in the modification of secondary bile acids to form 3β-bile acids (also known as iso-bile acids) via a 3-oxo intermediate. The enzyme catalyses a reversible reaction in vitro. Also acts on related bile acids. cf. EC, 3α-hydroxycholanate dehydrogenase (NAD+).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9028-57-3
1.  Devlin, A.S. and Fischbach, M.A. A biosynthetic pathway for a prominent class of microbiota-derived bile acids. Nat. Chem. Biol. 11 (2015) 685–690. [DOI] [PMID: 26192599]
[EC created 2016]

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